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  • Cesarean Scar Ectopic Pregnancy

    Cesarean scar ectopic pregnancy is a complication in which an embryonic pregnancy implants in the fibrous scar of a previous cesarean incision. This abnormally located pregnancy places the patient at increased risk for uterine dehiscence, hemorrhage, and abnormal placentation as the pregnancy progresses.

  • How Common Are Hormonal Side Effects with the 52-mg Levonorgestrel IUD?

    In this secondary analysis of the ACCESS IUS trial, participants who used combined hormonal contraceptives compared to nonhormonal contraceptives prior to enrolling were more likely to complain of acne in the first six months (13% vs. 8.5%, P = 0.006) and 12 months (15.7% vs. 10.6%, P = 0.005) of levonorgestrel intrauterine device use. Overall, the rate of discontinuation in the first six months because of adverse events was 5.5%, with no difference between the two groups.

  • Regret in Younger Patients After Minimally Invasive Hysterectomy

    A matched retrospective cohort study including 77 participants younger than 30 years of age and 164 participants aged 31-49 years demonstrated that a younger participant cohort had significantly higher rates of surgical and loss-of-fertility regret compared with an older participant cohort (32.5% vs. 9.1%, P < 0.001 and 39.0% vs. 13.4%, P < 0.001, respectively).

  • Preterm Birth and the RSV Vaccine During Pregnancy

    The follow-up MATISSE study explored the safety of the respiratory syncytial virus prefusion F (RSVpreF) vaccine in pregnant women and demonstrated no significant increase in preterm birth rates compared to the placebo, although it highlighted geographical and socioeconomic disparities in outcomes.

  • Wine Consumption and Cardiovascular Health

    A case-cohort subgroup of the PREDIMED study of older Mediterranean subjects at high cardiovascular disease risk, which used urinary tartaric acid to quantitate wine consumption, has shown over an almost five-year follow-up that light to moderate wine consumption was associated with a significant reduction in cardiovascular disease events.

  • Combustible vs. Electronic Cigarettes Post-PCI

    A large, nationwide South Korean study of smokers undergoing percutaneous coronary intervention (PCI) has shown that electronic cigarette use and smoking cessation resulted in similarly lower subsequent major adverse cardiac events compared to continued smoking.

  • Cardiovascular Risk with mRNA COVID Vaccines

    A large, nationwide population study in Sweden of the risk of adverse cardiovascular events after messenger ribonucleic acid (mRNA) COVID-19 vaccinations has shown that, except for rare cases of myopericarditis, severe cardiovascular events, such as myocardial infarction, heart failure, and stroke, are reduced, probably because of the prevention of COVID infection.

  • Indications for Bioprosthetic vs. Mechanical Aortic Valve Replacement

    A large U.S. database study comparing mechanical vs. bioprostheses for surgical aortic valve replacement in patients 40 to 75 years of age has shown that all-cause mortality is reduced with a mechanical valve in those age 60 years or younger.

  • POPular PAUSE TAVI Trial Supports Interrupting Oral Anticoagulation Before TAVR in Patients with Afib

    In this investigator-initiated, open-label trial, continuing oral anticoagulation leading up to a transcatheter aortic valve replacement procedure led to more bleeding and no reduction in thromboembolic events compared with interrupting anticoagulation.

  • Evaluation and Management of Elbow Injuries in the Emergency Department

    Elbow injuries continue to be a very common complaint that presents to the emergency department. These injuries involve a complex joint that includes many important structures, with injuries that vary greatly. It is important that emergency medicine clinicians remain prepared to evaluate, diagnose, and treat these various elbow injuries.